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Callyaerin B
General Information
DRACP ID DRACP00559
Peptide Name Callyaerin B
Sequence IXIILPPLXPII
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Callyspongia aerizusa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=5µM; IC90=30µM | Resazurin assay | 48h | 1 |
| L5178Y | Mouse leukemia | Leukemia | ED50=4.14µM | MTT assay | 72h | 2 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ED50>8µM | MTT assay | 72h | 2 |
| PC-12 | Lung papillary adenocarcinoma | Carcinoma | ED50>8µM | MTT assay | 72h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5:IC50=2µM; IC90=6µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond SMB: Ile1<--->X(9)
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(2)= 4-Hydroxyproline; X(9)=Daa
Chiral L
Physicochemical Information
Formula C57H96N10O9
Absent amino acids ACDEFGHKMNQRSTVWY
Common amino acids I
Mass 148185
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 7
Net charge 0
Boman Index 3444
Hydrophobicity 210.83
Aliphatic Index 227.5
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26213786
Title Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity
Doi 10.1021/acs.jnatprod.5b00266
Year 2015
Literature 2
Pubmed ID 20599387
Title Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.