Peptide Libraray

Callyaerin A

General Information

DRACP ID DRACP00560

Peptide Name Callyaerin A

Sequence IXVILPPLXPIFG

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Callyspongia aerizusa

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
THP-1	Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia	Leukemia	IC50=30µM; IC90=50µM	Resazurin assay	48h	1
L5178Y	Mouse leukemia	Leukemia	ED50=3.61µM	MTT assay	72h	2

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity MRC-5:IC50=20µM; IC90=40µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond SMB: Ile1<--->X(9)

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification X(2)= 4-Hydroxyproline; X(9)=Daa

Chiral L

Physicochemical Information

Formula C61H95N11O10

Absent amino acids ACDEHKMNQRSTWY

Common amino acids IP

Mass 157672

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 7

Net charge 0

Boman Index 3256

Hydrophobicity 176.15

Aliphatic Index 172.31

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26213786

Title Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity

Doi 10.1021/acs.jnatprod.5b00266

Year 2015

Literature 2

Pubmed ID 20599387

Title Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

Doi 10.1016/j.bmc.2010.06.012

Year 2010

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available