This work is licensed under a Creative Commons Attribution 4.0 International License.
DIM-LF11-318
General Information
DRACP ID DRACP00561
Peptide Name DIM-LF11-318
Sequence FWQRRIRRWRRFWQRRIRRWRR
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A-375 | Amelanotic melanoma | Carcinoma | LC50=9.3±0.8 µM | MTS assay | 24h | 1 |
| SBcl-2 | Serum B cell lymphoma 2 | Lymphoma | LC50=9.4±0.5 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=13.9±0.4 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C156H242N64O25
Absent amino acids ACDEGHKLMNPSTVY
Common amino acids R
Mass 378876
Pl 13.54
Basic residues 12
Acidic residues 0
Hydrophobic residues 8
Net charge 12
Boman Index -16500
Hydrophobicity -227.27
Aliphatic Index 35.45
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 22000
Absorbance 280nm 1047.62
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.