This work is licensed under a Creative Commons Attribution 4.0 International License.
LF11-322
General Information
DRACP ID DRACP00562
Peptide Name LF11-322
Sequence PFWRIRIRR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SBcl-2 | Serum B cell lymphoma 2 | Lymphoma | LC50>100 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=65.1±0.3 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H98N22O10
Absent amino acids ACDEGHKLMNQSTVY
Common amino acids R
Mass 144245
Pl 12.98
Basic residues 4
Acidic residues 0
Hydrophobic residues 4
Net charge 4
Boman Index -4453
Hydrophobicity -96.67
Aliphatic Index 86.67
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 687.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.