Peptide Libraray

R-DIM-P-LF11-322

General Information

DRACP ID DRACP00563

Peptide Name R-DIM-P-LF11-322

Sequence PFWRIRIRRPRRIRIRWFP

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Human lactoferricin derived

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A-375	Amelanotic melanoma	Carcinoma	LC50=23.3±1.7 µM	MTS assay	24h	1
SBcl-2	Serum B cell lymphoma 2	Lymphoma	LC50=10.4±0.7 µM	MTS assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF):LC50>101 µM

Target Not available

Affinity Not available

Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin

Nature Anticancer; Antitumor

Structure Information

PDB ID Not available

Predicted Structure DRACP00563

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C127H201N45O20

Absent amino acids ACDEGHKLMNQSTVY

Common amino acids R

Mass 299949

Pl 13.35

Basic residues 8

Acidic residues 0

Hydrophobic residues 8

Net charge 8

Boman Index -8906

Hydrophobicity -100

Aliphatic Index 82.11

Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?

Extinction Coefficient cystines 11000

Absorbance 280nm 611.11

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26239537

Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine

Doi 10.1016/j.bbamem.2015.07.018

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available