This work is licensed under a Creative Commons Attribution 4.0 International License.
R-DIM-LF11-337
General Information
DRACP ID DRACP00564
Peptide Name R-DIM-LF11-337
Sequence PFWRRRIRIRRRRIRIRRRWFP
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A-375 | Amelanotic melanoma | Carcinoma | LC50=61.8±0.1 µM | MTS assay | 24h | 1 |
| SBcl-2 | Serum B cell lymphoma 2 | Lymphoma | LC50=5.0±0.4 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=22.8±0.1 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C146H242N60O23
Absent amino acids ACDEGHKLMNQSTVY
Common amino acids R
Mass 358062
Pl 13.54
Basic residues 12
Acidic residues 0
Hydrophobic residues 8
Net charge 12
Boman Index -14874
Hydrophobicity -160.91
Aliphatic Index 70.91
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 11000
Absorbance 280nm 523.81
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.