Peptide Libraray

R-DIM-LF11-316

General Information

DRACP ID DRACP00565

Peptide Name R-DIM-LF11-316

Sequence RWKRINRQWFFWQRNIRKWR

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Human lactoferricin derived

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A-375	Amelanotic melanoma	Carcinoma	LC50=21.0±1.2 µM	MTS assay	24h	1
SBcl-2	Serum B cell lymphoma 2	Lymphoma	LC50=16.0±0.5 µM	MTS assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=61.8±0.1 µM

Target Not available

Affinity Not available

Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin

Nature Anticancer; Antitumor

Structure Information

PDB ID Not available

Predicted Structure DRACP00565

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C140H206N48O25

Absent amino acids ACDEGHLMPSTVY

Common amino acids R

Mass 330054

Pl 13.2

Basic residues 8

Acidic residues 0

Hydrophobic residues 8

Net charge 8

Boman Index -9986

Hydrophobicity -189

Aliphatic Index 39

Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?

Extinction Coefficient cystines 22000

Absorbance 280nm 1157.89

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26239537

Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine

Doi 10.1016/j.bbamem.2015.07.018

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available