This work is licensed under a Creative Commons Attribution 4.0 International License.
RW-AH
General Information
DRACP ID DRACP00566
Peptide Name RW-AH
Sequence WWRRWWRRWRRWWRRWWR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A-375 | Amelanotic melanoma | Carcinoma | LC50=13.9±0.4 µM | MTS assay | 24h | 1 |
| SBcl-2 | Serum B cell lymphoma 2 | Lymphoma | LC50=4.6±0.2 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=9.6±0.2 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C153H200N54O19
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids RW
Mass 340299
Pl 13.4
Basic residues 9
Acidic residues 0
Hydrophobic residues 9
Net charge 9
Boman Index -11331
Hydrophobicity -270
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 49500
Absorbance 280nm 2911.76
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.