This work is licensed under a Creative Commons Attribution 4.0 International License.
Chaxapeptin
General Information
DRACP ID DRACP00576
Peptide Name Chaxapeptin
Sequence GFGSKPLDSFGLNFF
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Streptomyces leeuwenhoekii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | 28% Inhibition=5µM(In a cell invasion assay); 56% Inhibition=50µM(In a cell invasion assay) | CyQuant stain assay (cell invasion) | 36h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H109N17O21
Absent amino acids ACEHIMQRTVWY
Common amino acids F
Mass 188272
Pl 6.34
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -313
Hydrophobicity 23.33
Aliphatic Index 52
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26402731
Title Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.