Peptide Libraray

HPRP-A1

General Information

DRACP ID DRACP00577

Peptide Name HPRP-A1

Sequence FKKLKKLFSKLWNWK

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
B16	Mouse melanoma	Carcinoma	IC50=6.1±0.02 μM	MTT assay	24h	1
SGC-7901	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=5.2±0.14 μM	MTT assay	24h	1
Hep-G2	Hepatoblastoma; Hepatoblastoma	Blastoma	IC50=7.7±0.23 μM	MTT assay	24h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=3.5±0.03 μM	MTT assay	24h	1

Hemolytic Activity Human RBC: MHC=64±6.80 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP00577

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C101H156N24O18

Absent amino acids ACDEGHIMPQRTVY

Common amino acids K

Mass 224439

Pl 11.5

Basic residues 6

Acidic residues 0

Hydrophobic residues 7

Net charge 6

Boman Index -1796

Hydrophobicity -83.33

Aliphatic Index 78

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 11000

Absorbance 280nm 785.71

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26405806

Title TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy

Doi 10.1371/journal.pone.0138911

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available