HPRP-A1-TAT

General Information


DRACP ID  DRACP00578

Peptide Name   HPRP-A1-TAT

Sequence  FKKLKKLFSKLWNWKRKKRRQRRR

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
B16 Mouse melanoma Carcinoma IC50=3.5±0.03 μM MTT assay 24h 1
SGC-7901 Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=4.8±0.08 μM MTT assay 24h 1
Hep-G2 Hepatoblastoma; Hepatoblastoma Blastoma IC50=5.8±0.36 μM MTT assay 24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=1.8±0.02 μM MTT assay 24h 1

Hemolytic Activity  Human RBC: MHC>500 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00578

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C154H260N54O28

Absent amino acids  ACDEGHIMPTVY

Common amino acids  K

Mass  372650

Pl  13.22

Basic residues  14

Acidic residues  0

Hydrophobic residues  7

Net charge  14

Boman Index  -12412

Hydrophobicity  -211.67

Aliphatic Index  48.75

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  478.26

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26405806

Title  TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy

Doi 10.1371/journal.pone.0138911

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.