This work is licensed under a Creative Commons Attribution 4.0 International License.
HPRP-A1-TAT
General Information
DRACP ID DRACP00578
Peptide Name HPRP-A1-TAT
Sequence FKKLKKLFSKLWNWKRKKRRQRRR
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16 | Mouse melanoma | Carcinoma | IC50=3.5±0.03 μM | MTT assay | 24h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=4.8±0.08 μM | MTT assay | 24h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=5.8±0.36 μM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.8±0.02 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human RBC: MHC>500 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C154H260N54O28
Absent amino acids ACDEGHIMPTVY
Common amino acids K
Mass 372650
Pl 13.22
Basic residues 14
Acidic residues 0
Hydrophobic residues 7
Net charge 14
Boman Index -12412
Hydrophobicity -211.67
Aliphatic Index 48.75
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 478.26
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26405806
Title TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy
Doi 10.1371/journal.pone.0138911
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.