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HPRP-A2
General Information
DRACP ID DRACP00579
Peptide Name HPRP-A2
Sequence FKKLKKLFSKLWNWK
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=8.65 ±0.38 μM | MTT assay | 24h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=10.42±0.30 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=21.38±0.56 μM | MTT assay | 24h | 1 |
| B16 | Mouse melanoma | Carcinoma | IC50=19.16±0.38 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: low toxicity
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C101H156N24O18
Absent amino acids ACDEGHIMPQRTVY
Common amino acids K
Mass 224439
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -1796
Hydrophobicity -83.33
Aliphatic Index 78
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 785.71
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26422386
Title In vitro Characterization of the Rapid Cytotoxicity of Anticancer Peptide HPRP-A2 through Membrane Destruction and Intracellular Mechanism against Gastric Cancer Cell Lines
Doi 10.1371/journal.pone.0139578
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.