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Ctn(Crotalicidin)
General Information
DRACP ID DRACP00582
Peptide Name Ctn(Crotalicidin)
Sequence KRFKKFFKKVKKSVKKRLKK工FKKPMVIGVTIPF
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Rattlesnake Venom Cathelicidin
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa S3 | Breast cancer | Carcinoma | IC50 < 1 µM | Resazurin assay | 4h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50 < 1 µM | Resazurin assay | 4h | 1 |
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=1.56 µM | Resazurin assay | 4h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50>12.5 µM | Resazurin assay | 4h | 1 |
| Jurkat E6.1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50>12.5 µM | Resazurin assay | 4h | 1 |
Hemolytic Activity Human erythrocytes: 7% and 33% hemolysis at 100 and 400 μM, respectively
Normal (non-cancerous) Cytotoxicity MM6: IC50=3.12 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula C197H332N52O35S
Absent amino acids ACDEHNQWY
Common amino acids K
Mass 460995
Pl 12.66
Basic residues 15
Acidic residues 0
Hydrophobic residues 12
Net charge 15
Boman Index -5885
Hydrophobicity -56.76
Aliphatic Index 68.53
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26465972
Title Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity
Doi 10.1021/acs.jmedchem.5b01142
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.