This work is licensed under a Creative Commons Attribution 4.0 International License.
YR
General Information
DRACP ID DRACP00583
Peptide Name YR
Sequence YGFVMPRSGLWFR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Spirulina (Arthrospira) platensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=188.23 μg/mL | MTT assay | 48h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=247.32 μg/mL | MTT assay | 48h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=104.05 μg/mL | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=446.72 μg/mL | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C78H110N20O16S
Absent amino acids ACDEHIKNQT
Common amino acids FGR
Mass 183012
Pl 11.15
Basic residues 2
Acidic residues 0
Hydrophobic residues 5
Net charge 2
Boman Index -1190
Hydrophobicity 8.46
Aliphatic Index 52.31
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 582.5
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26584028
Title Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.