This work is licensed under a Creative Commons Attribution 4.0 International License.
CTLEW
General Information
DRACP ID DRACP00584
Peptide Name CTLEW
Sequence CTLEW
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin walnut residual protein
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=0.60±0.17 mg/mL | MTT assay | 48h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | IC50=0.65±0.42 mg/mL | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity IEC-6: IC50>4 mg/mL; spleen lymphocytes: IC50>4 mg/mL.
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C29H42N6O9S
Absent amino acids ADFGHIKMNPQRSVY
Common amino acids CELTW
Mass 72228
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 2
Net charge -1
Boman Index -85
Hydrophobicity 24
Aliphatic Index 78
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 1375
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26593407
Title Isolation of a novel bio-peptide from walnut residual protein inducing apoptosis and autophagy on cancer cells
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.