This work is licensed under a Creative Commons Attribution 4.0 International License.
Pseudhymenochirin-2Pa [E27K]
General Information
DRACP ID DRACP00585
Peptide Name Pseudhymenochirin-2Pa [E27K]
Sequence GIFPIFAKLLGKVIKVASSLISKGRTK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=2.5±0.5µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=4.3±0.2µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=5.6±0.4µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
Hemolytic Activity Mouse erythrocytes:50% Hemolysis=4±1µM
Normal (non-cancerous) Cytotoxicity HUVEC: 50% Cell death=5.0±0.4µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification k=D-Lys
Chiral L
Physicochemical Information
Formula C136H235N35O32
Absent amino acids CDEHMNQWY
Common amino acids K
Mass 333652
Pl 12.05
Basic residues 6
Acidic residues 0
Hydrophobic residues 13
Net charge 6
Boman Index -52
Hydrophobicity 63.33
Aliphatic Index 130
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26606380
Title Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities
Doi 10.1021/acs.jnatprod.5b00843
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.