Peptide Libraray

Pseudhymenochirin-1Pb [E17k]

General Information

DRACP ID DRACP00586

Peptide Name Pseudhymenochirin-1Pb [E17k]

Sequence IKIPSFFRNILKKVGKkAVSLIAGALKQS

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	IC50=2.1±0.7µM	CellTiter-Glo Luminescent Cell Viability Assay	24h	1
MDA-MB-231	Breast adenocarcinoma	Carcinoma	IC50=3.6±0.5µM	CellTiter-Glo Luminescent Cell Viability Assay	24h	1
HT-29	Colon adenocarcinoma	Carcinoma	IC50=11±2µM	CellTiter-Glo Luminescent Cell Viability Assay	24h	1

Hemolytic Activity Mouse erythrocytes:50% Hemolysis=19±4µM

Normal (non-cancerous) Cytotoxicity HUVEC: 50% Cell death=5.0±0.5µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification k=D-Lys

Chiral Mix

Physicochemical Information

Formula C142H242N38O33

Absent amino acids CDEHMTWY

Common amino acids K

Mass 350934

Pl 12.05

Basic residues 6

Acidic residues 0

Hydrophobic residues 14

Net charge 6

Boman Index -926

Hydrophobicity 44.83

Aliphatic Index 124.48

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26606380

Title Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities

Doi 10.1021/acs.jnatprod.5b00843

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available