Peptide Libraray

Phylloseptin-Pba

General Information

DRACP ID DRACP00587

Peptide Name Phylloseptin-Pba

Sequence FFSMIPKIAGGIASLVKNL

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Phyllomedusa baltea

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H460	Lung large cell carcinoma	Carcinoma	IC50=4.3µM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=2.9µM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=1.8µM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: 1.4% Hemolysis=8µg/ml; Human erythrocytes: 80% Hemolysis=128µg/ml

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=36.6µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00587

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C95H156N22O23S

Absent amino acids CDEHQRTWY

Common amino acids I

Mass 232773

Pl 10.81

Basic residues 2

Acidic residues 0

Hydrophobic residues 10

Net charge 2

Boman Index 1791

Hydrophobicity 111.05

Aliphatic Index 128.42

Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26633506

Title Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity

Doi 10.3390/toxins7124878

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available