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Phylloseptin-PBa
General Information
DRACP ID DRACP00588
Peptide Name Phylloseptin-PBa
Sequence FFSMIPKIAGGIASLVKNLG
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H460 | Lung large cell carcinoma | Carcinoma | IC50=4.3 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=2.9 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=1.8 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse red cells: Phylloseptin-PBa was associated with a relatively low cytotoxicity (1.4%) on horse erythrocytes at a concentration of 8 mg/L, but this rose to around 80% at a concentration of 128 mg/L
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=36.6 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C97H159N23O24S
Absent amino acids CDEHQRTWY
Common amino acids GI
Mass 240262
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 10
Net charge 2
Boman Index 1885
Hydrophobicity 103.5
Aliphatic Index 122
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26633506
Title Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.