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B4
General Information
DRACP ID DRACP00589
Peptide Name B4
Sequence IRKLKSWKWLRWL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | Not active up to 170 µM | Trypan Blue exclusion assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H141N25O15
Absent amino acids ACDEFGHMNPQTVY
Common amino acids KLW
Mass 202749
Pl 12.55
Basic residues 5
Acidic residues 0
Hydrophobic residues 7
Net charge 5
Boman Index -2322
Hydrophobicity -63.85
Aliphatic Index 120
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 1375
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26902758
Title Combined Bioinformatic and Rational Design Approach To Develop Antimicrobial Peptides against Mycobacterium tuberculosis
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.