This work is licensed under a Creative Commons Attribution 4.0 International License.
ZXR-1
General Information
DRACP ID DRACP00594
Peptide Name ZXR-1
Sequence FKIGGFIKKLWRSKLA
Sequence Length 16
UniProt ID N0EAL3
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=62.6±8.4 µM | MTT assay | 6h | 1 |
| SACC-83 | Salivary gland adenoid cystic carcinoma | Carcinoma | IC50=27.9±7.7 µM | MTT assay | 6h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=69.1±1.6 µM | MTT assay | 6h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=77.9±0.9 µM | MTT assay | 6h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=141.7±12.2 µM | MTT assay | 6h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=186.7±13.1 µM; WPMY-1: IC50=283.3±19.0 µM
Target Not available
Affinity Not available
Mechanism ZXR-1 could internalize into cells by endocytosis, target on mitochondria, and induce cell apoptosis
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H150N24O18
Absent amino acids CDEHMNPQTVY
Common amino acids K
Mass 216010
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 8
Net charge 5
Boman Index -886
Hydrophobicity 8.75
Aliphatic Index 103.75
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27207743
Title From a pro-apoptotic peptide to a lytic peptide: One single residue mutation
Doi 0.1016/j.bbamem.2016.05.012
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.