This work is licensed under a Creative Commons Attribution 4.0 International License.
ZXR-2
General Information
DRACP ID DRACP00595
Peptide Name ZXR-2
Sequence FKIGGFIKKLWRSLLA
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=8.1±1.6 µM | MTT assay | 2h | 1 |
| SACC-83 | Salivary gland adenoid cystic carcinoma | Carcinoma | IC50=9.9±1.7 µM | MTT assay | 2h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=14.2±0.5 µM | MTT assay | 2h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=8.4±1.1 µm | MTT assay | 2h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=7.5±1.2 µM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=6.3±0.7 µM; WPMY-1: IC50=12.4±2.0 µM
Target Not available
Affinity Not available
Mechanism ZXR-2 could cause cell membrane lysis
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H149N23O18
Absent amino acids CDEHMNPQTVY
Common amino acids KL
Mass 214509
Pl 11.92
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index 161
Hydrophobicity 56.88
Aliphatic Index 128.13
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27207743
Title From a pro-apoptotic peptide to a lytic peptide: One single residue mutation
Doi 0.1016/j.bbamem.2016.05.012
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.