Api793

General Information


DRACP ID  DRACP00598

Peptide Name   Api793

Sequence  XWXWXRPVYXPRPRPPHPRL

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=640±150µg/ml MTT assay 24h 1

Hemolytic Activity  Human erythrocytes:1% Hemolysis=100µg/ml; Human erythrocytes:2% Hemolysis=600µg/ml

Normal (non-cancerous) Cytotoxicity  HEK293: 50% Cell death=640±50µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  gu=N , N , N ', N'-tetramethylguanidino)

C-terminal Modification  Free

Other Modification  X=Orn

Chiral  L



Physicochemical Information


Formula  C102H140N32O14

Absent amino acids  ACDEFGIKMNQST

Common amino acids  P

Mass  281748

Pl  12.5

Basic residues  5

Acidic residues  0

Hydrophobic residues  4

Net charge  5

Boman Index  -5086

Hydrophobicity  -129.5

Aliphatic Index  34

Half Life 
  /

Extinction Coefficient cystines  12490

Absorbance 280nm  657.37

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27243004

Title  N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa

Doi 2016

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.