This work is licensed under a Creative Commons Attribution 4.0 International License.
Api793
General Information
DRACP ID DRACP00598
Peptide Name Api793
Sequence XWXWXRPVYXPRPRPPHPRL
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=640±150µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:1% Hemolysis=100µg/ml; Human erythrocytes:2% Hemolysis=600µg/ml
Normal (non-cancerous) Cytotoxicity HEK293: 50% Cell death=640±50µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification gu=N , N , N ', N'-tetramethylguanidino)
C-terminal Modification Free
Other Modification X=Orn
Chiral L
Physicochemical Information
Formula C102H140N32O14
Absent amino acids ACDEFGIKMNQST
Common amino acids P
Mass 281748
Pl 12.5
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -5086
Hydrophobicity -129.5
Aliphatic Index 34
Half Life
/
Extinction Coefficient cystines 12490
Absorbance 280nm 657.37
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27243004
Title N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.