V681 [V13A]

General Information


DRACP ID  DRACP00600

Peptide Name   V681 [V13A]

Sequence  KWKSFLKTFKSAAKTVLHTALKAISS

Sequence Length  26

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=5.52 µM MTT assay 24h 1
A549 Lung adenocarcinoma Carcinoma IC50=6.83 µM MTT assay 24h 1
SGC-7901 Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=2.33 µM MTT assay 24h 1
B16 Mouse melanoma Carcinoma IC50=3.62 µM MTT assay 24h 1

Hemolytic Activity  Human erythrocytes: <5% Hemolysis=16 µM

Normal (non-cancerous) Cytotoxicity  3T3-L1: 50% Cell death=6.79 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00600

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C136H223N35O34

Absent amino acids  CDEGMNPQRY

Common amino acids  K

Mass  333858

Pl  11.5

Basic residues  7

Acidic residues  0

Hydrophobic residues  12

Net charge  7

Boman Index  -2002

Hydrophobicity  0.38

Aliphatic Index  86.54

Half Life 
  Mammalian:
  Yeast:
  E.coli:

Extinction Coefficient cystines  5500

Absorbance 280nm  220

Polar residues  7

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27363513

Title  Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy

Doi 10.1038/srep29145

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.