V681 [V13A]
General Information
DRACP ID DRACP00600
Peptide Name V681 [V13A]
Sequence KWKSFLKTFKSAAKTVLHTALKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=5.52 µM | MTT assay | 24h | 1 |
A549 | Lung adenocarcinoma | Carcinoma | IC50=6.83 µM | MTT assay | 24h | 1 |
SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=2.33 µM | MTT assay | 24h | 1 |
B16 | Mouse melanoma | Carcinoma | IC50=3.62 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=16 µM
Normal (non-cancerous) Cytotoxicity 3T3-L1: 50% Cell death=6.79 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C136H223N35O34
Absent amino acids CDEGMNPQRY
Common amino acids K
Mass 333858
Pl 11.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 12
Net charge 7
Boman Index -2002
Hydrophobicity 0.38
Aliphatic Index 86.54
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27363513
Title Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available