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V681 [V13E]
General Information
DRACP ID DRACP00601
Peptide Name V681 [V13E]
Sequence KWKSFLKTFKSAEKTVLHTALKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=109.68µM | MTT assay | 24h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=92.04µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:<5% Hemolysis=>500µM
Normal (non-cancerous) Cytotoxicity 3T3-L1:50% Cell death>125µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C138H225N35O36
Absent amino acids CDGMNPQRY
Common amino acids K
Mass 339661
Pl 11.1
Basic residues 7
Acidic residues 1
Hydrophobic residues 11
Net charge 6
Boman Index -2864
Hydrophobicity -20
Aliphatic Index 82.69
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27363513
Title Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.