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V681 [V13L]
General Information
DRACP ID DRACP00602
Peptide Name V681 [V13L]
Sequence KWKSFLKTFKSALKTVLHTALKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=4.86 µM | MTT assay | 24h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=2.80 µM | MTT assay | 24h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=2.0 µM | MTT assay | 24h | 1 |
| B16 | Mouse melanoma | Carcinoma | IC50=3.51 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=4 µM
Normal (non-cancerous) Cytotoxicity 3T3-L1: 50% Cell death=6.55 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C139H229N35O34
Absent amino acids CDEGMNPQRY
Common amino acids K
Mass 338066
Pl 11.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 12
Net charge 7
Boman Index -1691
Hydrophobicity 8.08
Aliphatic Index 97.69
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27363513
Title Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.