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P144
General Information
DRACP ID DRACP00604
Peptide Name P144
Sequence TSLDASIWAMMQNA
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin derived from the extracellular sequence of the human TGF-β type III receptor
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A172 | Glioblastoma | Blastoma | IC50=21.96±3.68 µg/mL | MTT assay | 48h | 1 |
| U-87MG ATCC | Glioblastoma | Blastoma | IC50=16.34±1.47 µg/mL | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Transforming Growth Factor beta
Affinity Not available
Mechanism P144 induced an upregulation of SMAD7 and downregulation of SKI through inhibition of the TGF-β pathway.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C65H103N17O22S2
Absent amino acids CEFGHKPRVY
Common amino acids A
Mass 177083
Pl 3.75
Basic residues 0
Acidic residues 1
Hydrophobic residues 6
Net charge -1
Boman Index -797
Hydrophobicity 27.14
Aliphatic Index 77.14
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 423.08
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27473823
Title P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines
Doi 10.1016/j.canlet.2016.07.029
Year 2016
Literature 2
Pubmed ID 12946101
Title A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
Doi 10.1016/s1043-4666(03)00101-7
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.