This work is licensed under a Creative Commons Attribution 4.0 International License.
NaD1 (1-7)-NaD2 (8-13)-NaD1 (14-47)
General Information
DRACP ID DRACP00605
Peptide Name NaD1 (1-7)-NaD2 (8-13)-NaD1 (14-47)
Sequence RECKTESHRFKGPCITKPPCRKACISEKFTDGHCSKILRRCLCTKPC
Sequence Length 47
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 22.2±2.4% Cell death=10µM | PI uptake assay | 30min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys23<--->Cys47; Cys14<---Cys34; Cys20<--->Cys41; Cys24<--->Cys43
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C227H381N73O63S8
Absent amino acids MNQVWY
Common amino acids C
Mass 621812
Pl 9.32
Basic residues 14
Acidic residues 4
Hydrophobic residues 8
Net charge 10
Boman Index -12791
Hydrophobicity -72.55
Aliphatic Index 43.62
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 500
Absorbance 280nm 10.87
Polar residues 17
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27503651
Title Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.