NaD1 (1-34)-NaD2 (35-40)-NaD1 (41-47)

General Information


DRACP ID  DRACP00607

Peptide Name   NaD1 (1-34)-NaD2 (35-40)-NaD1 (41-47)

Sequence  RECKTESNTFPGICITKPPCRKACISEKFTDGHCRGFRRRCLCTKPC

Sequence Length  47

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia Leukemia 13.7±8.1% Cell death=10µM PI uptake assay 30min 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00607

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys23<--->Cys47; Cys14<---Cys34; Cys20<--->Cys41; Cys24<--->Cys43

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C225H371N73O64S8

Absent amino acids  MQVWY

Common amino acids  C

Mass  620001

Pl  9.03

Basic residues  12

Acidic residues  4

Hydrophobic residues  8

Net charge  8

Boman Index  -13388

Hydrophobicity  -68.94

Aliphatic Index  35.32

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  500

Absorbance 280nm  10.87

Polar residues  19

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27503651

Title  Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

Doi 10.1128/AAC.01479-16

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.