This work is licensed under a Creative Commons Attribution 4.0 International License.
Warnericin RK [G20D]
General Information
DRACP ID DRACP00613
Peptide Name Warnericin RK [G20D]
Sequence MQFITDLIKKAVDFFKGLFDNK
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | LD50=5.39µM | PI staining assay | Not available | 1 |
Hemolytic Activity Human erythrocytes:10% Hemolysis=12.36µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C124H192N28O32S
Absent amino acids CEHPRSWY
Common amino acids FK
Mass 299389
Pl 9.37
Basic residues 4
Acidic residues 3
Hydrophobic residues 10
Net charge 1
Boman Index -2237
Hydrophobicity 6.82
Aliphatic Index 88.64
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27598770
Title Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging
Doi 10.1371/journal.pone.0162007
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.