This work is licensed under a Creative Commons Attribution 4.0 International License.
Warnericin RK [F14V]
General Information
DRACP ID DRACP00614
Peptide Name Warnericin RK [F14V]
Sequence MQFITDLIKKAVDVFKGLFGNK
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | LD50=8.79µM | PI staining assay | Not available | 1 |
Hemolytic Activity Human erythrocytes:10% Hemolysis=12.5µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C118H190N28O30S
Absent amino acids CEHPRSWY
Common amino acids K
Mass 288781
Pl 10.33
Basic residues 4
Acidic residues 2
Hydrophobic residues 10
Net charge 2
Boman Index -1165
Hydrophobicity 27.27
Aliphatic Index 101.82
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27598770
Title Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging
Doi 10.1371/journal.pone.0162007
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.