CecXJ-37N

General Information


DRACP ID  DRACP00615

Peptide Name   CecXJ-37N

Sequence  RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAIGK

Sequence Length  37

UniProt ID  Not available

PubChem CID  Not available

Origin  Bombyx mori

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Eca 109 Esophageal squamous cell carcinoma; Squamous cell carcinoma of the esophagus Carcinoma 30% Killing=20µM MTT assay 24h 1

Hemolytic Activity  Human erythrocytes: 5% Hemolysis=134.6µg/ml

Normal (non-cancerous) Cytotoxicity  NIH 3T3: Not active up to 20 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00615

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C185H317N55O46S

Absent amino acids  CHQTY

Common amino acids  K

Mass  472228

Pl  11.46

Basic residues  10

Acidic residues  3

Hydrophobic residues  15

Net charge  7

Boman Index  -5387

Hydrophobicity  -24.32

Aliphatic Index  100.27

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  152.78

Polar residues  7

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27664674

Title  A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack

Doi 10.1016/j.foodchem.2016.09.033

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.