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MCoAA-01
General Information
DRACP ID DRACP00622
Peptide Name MCoAA-01
Sequence CGRRKRRRGCRRDSDCPGACICRYwKVCGSGSDGGV
Sequence Length 36
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=45.01±0.16 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=40.12±0.13 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=10.83±0.09 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification w=D-Tryptophane
Chiral Mix
Physicochemical Information
Formula C146H251N61O45S6
Absent amino acids EFHLMNQTW
Common amino acids R
Mass 439781
Pl 9.69
Basic residues 10
Acidic residues 3
Hydrophobic residues 4
Net charge 7
Boman Index -13789
Hydrophobicity -90.83
Aliphatic Index 29.72
Half Life
/
Extinction Coefficient cystines 1865
Absorbance 280nm 53.29
Polar residues 17
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.