This work is licensed under a Creative Commons Attribution 4.0 International License.
MCo-polyR-L6
General Information
DRACP ID DRACP00623
Peptide Name MCo-polyR-L6
Sequence CPKILKKCRRDSDCPGACICRGNGYCGRRKRRRG
Sequence Length 34
UniProt ID P82409
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=52.89±0.11 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=34.95±0.03 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C155H273N63O42S6
Absent amino acids EFHMQTVW
Common amino acids R
Mass 447243
Pl 10.82
Basic residues 12
Acidic residues 2
Hydrophobic residues 4
Net charge 10
Boman Index -14023
Hydrophobicity -117.06
Aliphatic Index 37.35
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1865
Absorbance 280nm 56.52
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.