This work is licensed under a Creative Commons Attribution 4.0 International License.
MCo-SST-02
General Information
DRACP ID DRACP00625
Peptide Name MCo-SST-02
Sequence CPKILKKCRRDSDCPGACICRGNGYCRFwKTW
Sequence Length 32
UniProt ID P82409
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=70.61±0.11 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=83.55±0.20 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=58.89±0.09 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50>100 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification w=D-Tryptophane
Chiral Mix
Physicochemical Information
Formula C151H243N49O39S6
Absent amino acids EHMQV
Common amino acids C
Mass 411439
Pl 9.2
Basic residues 8
Acidic residues 2
Hydrophobic residues 6
Net charge 6
Boman Index -7969
Hydrophobicity -61.88
Aliphatic Index 39.69
Half Life
/
Extinction Coefficient cystines 7365
Absorbance 280nm 237.58
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.