This work is licensed under a Creative Commons Attribution 4.0 International License.
MCo-PEDF
General Information
DRACP ID DRACP00626
Peptide Name MCo-PEDF
Sequence CPKILKKCRRDSDCPGACICRGNGYCYHLNQPF
Sequence Length 33
UniProt ID P82409
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=53.44±0.14 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=39.11±0.07 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=35.22±0.08 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=50.16±0.15 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C159H252N50O44S6
Absent amino acids EMTVW
Common amino acids C
Mass 433140
Pl 8.62
Basic residues 7
Acidic residues 2
Hydrophobic residues 6
Net charge 5
Boman Index -7104
Hydrophobicity -57.88
Aliphatic Index 50.3
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 3355
Absorbance 280nm 104.84
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.