This work is licensed under a Creative Commons Attribution 4.0 International License.
MCoAA-02
General Information
DRACP ID DRACP00628
Peptide Name MCoAA-02
Sequence CPKILKKCRRDSDCPGACICRYwKVCGYHLNQPFG
Sequence Length 35
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=35.44±0.13 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=19.75±0.07 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=27.06±0.06 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification w=D-Tryptophane
Chiral Mix
Physicochemical Information
Formula C166H265N51O43S6
Absent amino acids EMTW
Common amino acids C
Mass 446226
Pl 8.87
Basic residues 8
Acidic residues 2
Hydrophobic residues 7
Net charge 6
Boman Index -6591
Hydrophobicity -43.71
Aliphatic Index 55.71
Half Life
/
Extinction Coefficient cystines 3355
Absorbance 280nm 98.68
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.