MCo-polyR-L1
General Information
DRACP ID DRACP00629
Peptide Name MCo-polyR-L1
Sequence CRRKRRRCRRDSDCPGACICRGNGYCGSGSDGGV
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
PC-3 | Prostate carcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
HT-29 | Colon adenocarcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50>100 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H238N60O46S6
Absent amino acids EFHLMQTW
Common amino acids R
Mass 426695
Pl 9.22
Basic residues 9
Acidic residues 3
Hydrophobic residues 3
Net charge 6
Boman Index -14302
Hydrophobicity -107.35
Aliphatic Index 22.94
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1865
Absorbance 280nm 56.52
Polar residues 18
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available