This work is licensed under a Creative Commons Attribution 4.0 International License.
SFTI-polyR-L2
General Information
DRACP ID DRACP00633
Peptide Name SFTI-polyR-L2
Sequence CTKSIPPICRRKRRR
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=41.84±0.07 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50>100 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C77H144N32O18S2
Absent amino acids ADEFGHLMNQVWY
Common amino acids R
Mass 212019
Pl 12.34
Basic residues 7
Acidic residues 0
Hydrophobic residues 2
Net charge 7
Boman Index -7927
Hydrophobicity -140
Aliphatic Index 52
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 8.93
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.