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SFTI-PEDF
General Information
DRACP ID DRACP00634
Peptide Name SFTI-PEDF
Sequence CTKSIPPICYHLNQPF
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=27.89±0.11 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C85H129N21O22S2
Absent amino acids ADEGMRVW
Common amino acids P
Mass 212894
Pl 8.23
Basic residues 2
Acidic residues 0
Hydrophobic residues 4
Net charge 2
Boman Index -820
Hydrophobicity -6.88
Aliphatic Index 73.13
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1615
Absorbance 280nm 107.67
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.