This work is licensed under a Creative Commons Attribution 4.0 International License.
IL-1
General Information
DRACP ID DRACP00640
Peptide Name IL-1
Sequence FKAGGFIKKLWRSLLA
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=73.9±13.6 μM | MTT assay | 2h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=58.4±13.7 μM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=24.1±3.2 μM; WPMY-1: IC50=43.2±4.9 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H143N23O18
Absent amino acids CDEHMNPQTVY
Common amino acids KL
Mass 210301
Pl 11.92
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index -150
Hydrophobicity 40
Aliphatic Index 110
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27778166
Title Isoleucine/leucine residues at "a" and "d" positions of a heptad repeat sequence are crucial for the cytolytic activity of a short anticancer lytic peptide
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.