BmKn-2

General Information


DRACP ID  DRACP00647

Peptide Name   BmKn-2

Sequence  FIGAIARLLSKIF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Scorpion venom

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HSC-4 Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue Carcinoma IC50=29 μg/mL MTT assay 24h 1
HSC-4 Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue Carcinoma IC50=26 μg/mL MTT assay 24h 1
KB Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=34 μg/mL MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00647

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C71H117N17O15

Absent amino acids  CDEHMNPQTVWY

Common amino acids  I

Mass  166305

Pl  11.65

Basic residues  2

Acidic residues  0

Hydrophobic residues  9

Net charge  2

Boman Index  1125

Hydrophobicity  159.23

Aliphatic Index  165.38

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27780132

Title  The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells

Doi 10.1016/j.biopha.2016.10.041

Year  2015

Literature 2

Pubmed ID 25854366

Title  BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis

Doi 10.7314/apjcp.2015.16.7.2807

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.