This work is licensed under a Creative Commons Attribution 4.0 International License.
BmKn-2
General Information
DRACP ID DRACP00647
Peptide Name BmKn-2
Sequence FIGAIARLLSKIF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Scorpion venom
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | IC50=29 μg/mL | MTT assay | 24h | 1 |
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | IC50=26 μg/mL | MTT assay | 24h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=34 μg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H117N17O15
Absent amino acids CDEHMNPQTVWY
Common amino acids I
Mass 166305
Pl 11.65
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 1125
Hydrophobicity 159.23
Aliphatic Index 165.38
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27780132
Title The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells
Doi 10.1016/j.biopha.2016.10.041
Year 2015
Literature 2
Pubmed ID 25854366
Title BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis
Doi 10.7314/apjcp.2015.16.7.2807
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.