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LL-37 KR-12
General Information
DRACP ID DRACP00648
Peptide Name LL-37 KR-12
Sequence KRIVQRIKDFLR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CaCo-2 | Colon adenocarcinoma | Carcinoma | EC50=125µg/ml | MTT assay | 24h | 1 |
| A431 | Skin squamous cell carcinoma | Carcinoma | EC50=31.2µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>800µM; 10.6% Hemolysis=100µM; <5% Hemolysis=256µg/ml; Rabbit erythrocytes: 73% Hemolysis=125µg/ml
Normal (non-cancerous) Cytotoxicity NIH 3T3: EC50=0.8µg/ml; HaCat: IC50=74.6µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H126N24O16
Absent amino acids ACEGHMNPSTWY
Common amino acids R
Mass 176832
Pl 12.24
Basic residues 5
Acidic residues 1
Hydrophobic residues 5
Net charge 4
Boman Index -4834
Hydrophobicity -70.83
Aliphatic Index 121.67
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27907988
Title KR12 peptide associated with cyclodextrin: Antimicrobial and antitumor activities
Year 2016
Literature 2
Pubmed ID 24105706
Title Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity
Doi 10.1002/psc.2552
Year 2013
Literature 3
Pubmed ID 24307932
Title Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37
Year 2013
Literature 4
Pubmed ID 32019109
Title Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12-Structural Analysis, Surface-Active Properties and Antimicrobial Activity
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.