TetraF2W-KK
General Information
DRACP ID DRACP00649
Peptide Name TetraF2W-KK
Sequence WWWLKKIW
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=70µM | MTS assay | Not available | 1 |
Hemolytic Activity Human erythrocytes:50% Hemolysis=40µM; Pig erythrocytes:50% Hemolysis=55µM; Chicken erythrocytes:50% Hemolysis=50µM
Normal (non-cancerous) Cytotoxicity HEK293:50% Cell death=50µM; HaCat:50% Cell death=50µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H88N14O9
Absent amino acids ACDEFGHMNPQRSTVY
Common amino acids W
Mass 137058
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 6
Net charge 2
Boman Index 806
Hydrophobicity -38.75
Aliphatic Index 97.5
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 3142.86
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27915018
Title Design and surface immobilization of short anti-biofilm peptides
Doi 10.1016/j.actbio.2016.11.061
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available