This work is licensed under a Creative Commons Attribution 4.0 International License.
TetraF2W-RR
General Information
DRACP ID DRACP00652
Peptide Name TetraF2W-RR
Sequence WWWLRRIW
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LC50=60µM | MTS assay | Not available | 1 |
Hemolytic Activity Human erythrocytes:50% Hemolysis=20µM; Pig erythrocytes:50% Hemolysis=40µM; Chicken erythrocytes:50% Hemolysis=55µM
Normal (non-cancerous) Cytotoxicity HEK293:50% Cell death=70µM; HaCat:50% Cell death=70µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H88N18O9
Absent amino acids ACDEFGHKMNPQSTVY
Common amino acids W
Mass 142660
Pl 12.5
Basic residues 2
Acidic residues 0
Hydrophobic residues 6
Net charge 2
Boman Index -1068
Hydrophobicity -53.75
Aliphatic Index 97.5
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 3142.86
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27915018
Title Design and surface immobilization of short anti-biofilm peptides
Doi 10.1016/j.actbio.2016.11.061
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.