This work is licensed under a Creative Commons Attribution 4.0 International License.
Leucocin A (18-35)
General Information
DRACP ID DRACP00653
Peptide Name Leucocin A (18-35)
Sequence WGEAFSAGVHRLANGGNG
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50>64µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:10% Hemolysis>71.15µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C78H114N26O24
Absent amino acids CDIKMPQTY
Common amino acids G
Mass 210334
Pl 7.55
Basic residues 2
Acidic residues 1
Hydrophobic residues 7
Net charge 1
Boman Index -1867
Hydrophobicity -31.67
Aliphatic Index 54.44
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 323.53
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28002968
Title Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles
Doi 10.1021/acs.jmedchem.6b00922
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.