Leucocin A (18-35)[E3R;A7R;H10R;N14,17R]

General Information


DRACP ID  DRACP00658

Peptide Name   Leucocin A (18-35)[E3R;A7R;H10R;N14,17R]

Sequence  WGRAFSRGVRRLARGGRG

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma IC50=64µM MTT assay 24h 1

Hemolytic Activity  Human erythrocytes:10% Hemolysis>63.54µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00658

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C86H143N37O20

Absent amino acids  CDEHIKMNPQTY

Common amino acids  R

Mass  231871

Pl  13.2

Basic residues  6

Acidic residues  0

Hydrophobic residues  6

Net charge  6

Boman Index  -7033

Hydrophobicity  -90.56

Aliphatic Index  48.89

Half Life 
  Mammalian: 2.8 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  323.53

Polar residues  6

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28002968

Title  Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles

Doi 10.1021/acs.jmedchem.6b00922

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.