This work is licensed under a Creative Commons Attribution 4.0 International License.
AM-CATH36
General Information
DRACP ID DRACP00667
Peptide Name AM-CATH36
Sequence GLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR
Sequence Length 36
UniProt ID Not available
PubChem CID Not available
Origin Alligator mississippiensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | Not active up to 100 µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Sheep erythrocytes(Not active up to 300 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C194H337N57O38
Absent amino acids CDEHMNQTWY
Common amino acids K
Mass 470063
Pl 13.01
Basic residues 13
Acidic residues 0
Hydrophobic residues 14
Net charge 13
Boman Index -5014
Hydrophobicity -24.72
Aliphatic Index 105.56
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28089718
Title Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.