This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclosporin A
General Information
DRACP ID DRACP00669
Peptide Name Cyclosporin A
Sequence XXXVXAaXXXX
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Tolypocladium inflatum
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | 0% Killing=8µM; 50% Killing=17µM | CellTiter-Glo Luminescent Cell Viability Assay | Not available | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | 0% Killing=12µM; 20% Killing=17µM | CellTiter-Glo Luminescent Cell Viability Assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero E6: <10% Killing=5µM, 25% Killing=17µM; Fcwf-4: 0% Killing=4µM, 40% Killing=12µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: X(1)<--->X(11)
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(1)=alpha-Aminobutyrate; X(2)=Sarcosine; X(3)=METH-Leu; X(5)=METH-Leu; X(7)=D-Ala; X(8)=METH-Leu; X(9)=METH-Leu; X(10)=METH-Val; X(11)=N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Chiral Mix
Physicochemical Information
Formula C8H-2N2O-6
Absent amino acids CDEFGHIKLMNPQRSTWY
Common amino acids X
Mass 108463
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 585
Hydrophobicity 54.55
Aliphatic Index 35.45
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28137809
Title A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.