This work is licensed under a Creative Commons Attribution 4.0 International License.
Bacteriocin TP
General Information
DRACP ID DRACP00670
Peptide Name Bacteriocin TP
Sequence ASVVNKLTGGVAGLLK
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Bacillus subtilis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MKN 45 | Gastric adenocarcinoma | Carcinoma | IC50=4.686µM | MTT assay | 48h | 1 |
| NB4 | Acute promyelocytic leukemia with PML-RARA ; Acute promyelocytic leukemia | Leukemia | IC50=11.479µM | MTT assay | 48h | 1 |
Hemolytic Activity Mouse erythrocytes: <10% Hemolysis=160µM; 10% Hemolysis=320µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H123N19O20
Absent amino acids CDEFHIMPQRWY
Common amino acids GLV
Mass 179459
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 961
Hydrophobicity 85
Aliphatic Index 140
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28254375
Title Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium
Doi 10.1016/j.ijantimicag.2016.12.012
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.